Description

(+-)-Colchicine CAS NO 54192-66-4 is a naturally occurring alkaloid and a potent microtubule polymerization inhibitor. This compound is of significant interest in pharmaceutical research and development due to its unique biological activity. It serves as a critical reference standard and active pharmaceutical ingredient (API) for researchers and manufacturers in the life sciences sector, particularly for studying cellular processes and developing therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments, method validation, and quality control testing of colchicine-based drug products.
• Biochemical Research: A vital tool for studying microtubule dynamics, cell division (mitosis), and intracellular transport mechanisms in vitro.
• Active Pharmaceutical Ingredient (API): Serves as the key therapeutic component in the formulation of medications, primarily for the treatment and prevention of gout flares and familial Mediterranean fever (FMF).
• Preclinical Studies: Employed in animal models to investigate pharmacokinetics, pharmacodynamics, and the therapeutic potential for various inflammatory and fibrotic conditions.
• Academic Research: Utilized in university and institutional labs for fundamental research in cell biology, pharmacology, and toxicology.

Basic Information

Product Name	(+-)-Colchicine
CAS No.	54192-66-4
Molecular Formula	C22H25NO6
Molecular Weight	399.44 g/mol
Synonyms	Colchicine; Colchicine (racemic); (±)-Colchicine; NSC 757; SR 0514; SR-0514; Colchicina; Colchicin; Colchiceine Methyl Ether; 7-Acetamido-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one
EINECS	Contact for details

Quality Control

Our (+-)-Colchicine is manufactured and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) detailing all test results are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.