Description

Antipyrine, [n-Methyl-14C] CAS NO 53890-74-7 is a carbon-14 labeled derivative of the classic analgesic and antipyretic compound, antipyrine. This radiolabeled version is essential for conducting precise metabolic and pharmacokinetic studies in drug development and biochemical research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions specializing in pharmacology and toxicology.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of drug candidates and related compounds.
• Biochemical Pathway Analysis: Enables the tracking of metabolic pathways and the identification of metabolites in in vitro and in vivo systems.
• Analytical Method Development: Serves as a critical reference standard for developing and validating sensitive analytical methods, such as Liquid Chromatography-Mass Spectrometry (LC-MS) and Scintillation Counting.
• Enzyme Activity and Inhibition Assays: Employed in studies to assess the activity of cytochrome P450 enzymes and other metabolic enzymes.
• Toxicology and Safety Assessment: Facilitates mass balance studies and tissue distribution analysis in preclinical safety evaluations.

Basic Information

Product Name	Antipyrine, [n-Methyl-14C]
CAS No.	53890-74-7
Molecular Formula	C11H12N2O * (14C)
Molecular Weight	~188.23 g/mol (unlabeled)
Synonyms	1-Phenyl-2,3-dimethyl-5-pyrazolone-[N-methyl-14C]; Phenazone-[N-methyl-14C]; [N-methyl-14C]Antipyrine; 14C-Labeled Antipyrine; 2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one-[N-methyl-14C]; Analgesine-[14C]; Parodyne-[14C]; Sedatine-[14C]
EINECS	Contact for details

Quality Control

Every batch of our carbon-14 labeled Antipyrine is manufactured and analyzed under strict quality systems to ensure high chemical and radiochemical purity, specific activity, and stability. Comprehensive Certificates of Analysis (COA) are provided, detailing results for identity, purity, radiochemical concentration, and solvent content. Our production adheres to cGMP principles where applicable, supporting regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures, typically between 2°C and 8°C (refrigerated) or as specified on the label. Store in accordance with all local and national regulations for radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid or solution
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (if supplied as solution)	Specified (e.g., Ethanol, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.