Description

Abrin C CAS NO 53597-24-3 is a highly potent plant-derived protein toxin belonging to the type II ribosome-inactivating protein (RIP) family. This compound is of significant interest in biochemical research and pharmaceutical development due to its specific mechanism of action, which inhibits protein synthesis. It is primarily utilized by research institutions, diagnostic manufacturers, and biotechnology companies for applications in targeted cell studies, immunotoxin development, and as a critical reference standard.

Application

• Biomedical Research: Used as a tool compound to study mechanisms of protein synthesis inhibition, apoptosis, and intracellular trafficking.
• Immunoconjugate Development: Serves as a cytotoxic payload in the research and development of antibody-drug conjugates (ADCs) and other targeted therapies.
• Diagnostic Reagent Manufacturing: Employed in the production of control materials and calibrators for certain diagnostic assays.
• Toxicology Studies: Acts as a reference standard in forensic and environmental toxicology for identification and quantification purposes.
• Cell Biology: Utilized in selective cell ablation experiments to understand cell lineage and function in model systems.
• Biodefense Research: Studied in controlled laboratory settings for the development of detection methods and medical countermeasures.

Basic Information

Product Name	Abrin C
CAS No.	53597-24-3
Molecular Formula	C~n~H~m~N~x~O~y~S~z~ (Protein)
Molecular Weight	~60-65 kDa
Synonyms	Abrin; Abrin Toxin; Abrin-I; Abrin A-Chain; Ricin-like Toxin from Abrus precatorius; Lectin from Abrus precatorius; Abrus Agglutinin; Abrus Precatorius Lectin; Precatorine; Toxalbumin from Abrus precatorius
EINECS	Contact for details

Quality Control

Our Abrin C is produced and handled under stringent quality management protocols. Each batch is characterized using advanced analytical techniques including SDS-PAGE, HPLC, and mass spectrometry to ensure identity, purity, and activity. Certificates of Analysis (COA) detailing specific purity, biological activity (e.g., IC50 in cell-based assays), and endotoxin levels are provided to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE & MS)	Conforms
Purity (HPLC)	≥ 95%
Protein Content (UV)	≥ 90%
Biological Activity (Cell-based assay)	Reported per batch
Endotoxin (LAL)	< 10 EU/mg
Solubility	Soluble in PBS or suitable aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.