Description

Glycine Ethyl Ester Hydrochloride, [Glycine 2-14C] CAS NO 53543-67-2 is a radiolabeled derivative of the amino acid glycine, where the carbon at the 2-position is the carbon-14 isotope. This compound is a critical building block and tracer in biochemical and pharmaceutical research, enabling precise metabolic and pharmacokinetic studies. It is essential for scientists and manufacturers in the fields of radiopharmaceutical development, drug metabolism research, and proteomics who require high-specific-activity, chemically defined tracers.

Application

• Radiolabeled Precursor in API Synthesis: Used as a carbon-14 labeled intermediate in the synthesis of isotopically labeled Active Pharmaceutical Ingredients (APIs) for absorption, distribution, metabolism, and excretion (ADME) studies.
• Metabolic Pathway Tracing: Serves as a tracer to study glycine metabolism, one-carbon metabolism, and the biosynthesis of compounds like glutathione, purines, and heme in biological systems.
• Proteomics and Peptide Research: Employed in the radiolabeling of peptides and proteins to investigate protein folding, interactions, and degradation pathways.
• Biochemical Assay Development: Utilized as a standard or reagent in the development of sensitive assays for enzyme activity (e.g., glycine cleavage system) or transporter function.
• Neuropharmacology Research: Applied in studies investigating the role of glycine as an inhibitory neurotransmitter and co-agonist at NMDA receptors in the central nervous system.
• Agricultural Chemical Research: Used as a tracer in environmental fate studies and metabolic research of agrochemicals in plants.

Basic Information

Product Name	Glycine Ethyl Ester Hydrochloride, [Glycine 2-14C]
CAS No.	53543-67-2
Molecular Formula	C4H9NO2•HCl (with 14C at C-2)
Molecular Weight	139.58 g/mol (unlabeled)
Synonyms	Ethyl Glycinate Hydrochloride, [2-14C]; 2-Aminoacetic Acid Ethyl Ester Hydrochloride, [2-14C]; Glycine Ethyl Ester HCl, [2-14C]; Ethyl 2-Aminoacetate Hydrochloride, [2-14C]; H-Gly-OEt•HCl, [2-14C]; [2-14C]Glycine Ethyl Ester Hydrochloride; Aminoacetic Acid Ethyl Ester Hydrochloride, Labeled
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled compounds is produced and analyzed under stringent quality control protocols to ensure high chemical and radiochemical purity, specific activity, and stability. Comprehensive analysis is performed using HPLC with radiometric detection, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, specific activity (mCi/mmol or GBq/mmol), solvent composition, and analytical chromatograms. Our quality system supports research compliant with GLP and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the primary container sealed within a secondary container with desiccant. Follow all local and international regulations for the safe handling and disposal of radioactive materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (HPLC)	Conforms to reference standard
Chemical Purity (HPLC)	≥ 98.0%
Radiochemical Purity (HPLC)	≥ 97.0%
Specific Activity	50-60 mCi/mmol (1.85-2.22 GBq/mmol) [Custom ranges available]
Solvent (for solutions)	Ethanol, Water, or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.