Description

(2R,3S)-2,3-Bis(Trimethylsiloxy)Butanedioic Acid Dimethyl Ester is a high-purity, chiral organosilicon compound primarily used as a key synthetic intermediate in advanced organic synthesis. Its value lies in its role as a protected derivative of tartaric acid, enabling stereoselective transformations critical for producing complex molecules. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality building blocks for asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of antiviral, anticancer, and cardiovascular drugs.
• Asymmetric Catalyst Ligand Precursor: Used in the preparation of chiral ligands for transition metal catalysts, which are vital for enantioselective hydrogenation and other stereospecific reactions.
• Agrochemical Synthesis: Serves as an intermediate in the production of chiral herbicides, fungicides, and plant growth regulators where specific stereochemistry is required for biological activity.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances that demand high enantiomeric purity.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and process optimization in pilot-scale manufacturing.

Basic Information

Product Name	(2R,3S)-2,3-Bis(Trimethylsiloxy)Butanedioic Acid Dimethyl Ester
CAS No.	53319-85-0
Molecular Formula	C12H26O6Si2
Molecular Weight	322.51 g/mol
Synonyms	Dimethyl (2R,3S)-2,3-Bis[(trimethylsilyl)oxy]succinate; (2R,3S)-2,3-Di-O-trimethylsilyl-D-tartaric Acid Dimethyl Ester; D-(-)-Di-O-trimethylsilyltartaric Acid Dimethyl Ester; (2R,3S)-2,3-Bis(trimethylsiloxy)succinic Acid Dimethyl Ester; (2R,3S)-Di-O-TMS-tartrate Dimethyl Ester; TMS-protected D-Tartaric Acid Dimethyl Ester; 53319-85-0; L 029,077
EINECS	Contact for details

Quality Control

Our (2R,3S)-2,3-Bis(Trimethylsiloxy)Butanedioic Acid Dimethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical and enantiomeric purity, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from incompatible materials such as strong acids and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.