Description

Estrone-[2,4,6,7-3H(N)] is a high-specific-activity, tritium-labeled derivative of the natural estrogen, estrone. This radiochemical is essential for sensitive and accurate research in endocrinology and metabolism, enabling precise tracking and quantification of estrone in complex biological systems. It is a critical reagent for pharmaceutical R&D, clinical research, and environmental analysis laboratories requiring advanced tracer studies.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) of estrone and related compounds in preclinical research.
• Receptor Binding Assays: Employed in competitive binding studies to determine the affinity of novel compounds for estrogen receptors (ERα and ERβ).
• Analytical Method Development: Serves as an internal standard or recovery tracer in the development and validation of highly sensitive LC-MS/MS or radio-HPLC methods for hormone analysis.
• Environmental Fate Studies: Applied in research investigating the environmental breakdown, bioaccumulation, and transport of estrogenic compounds.
• Diagnostic Kit Manufacturing: Utilized in the production of radioimmunoassay (RIA) kits for the clinical measurement of estrogen levels.

Basic Information

Product Name	Estrone-[2,4,6,7-3H(N)]
CAS No.	52788-75-7
Molecular Formula	C₁₈H₂₂O₂ (³H-labeled)
Molecular Weight	~270.4 g/mol (varies with specific activity)
Synonyms	1,3,5(10)-Estratrien-3-ol-17-one-[2,4,6,7-³H]; [2,4,6,7-³H]Estrone; 3-Hydroxy-1,3,5(10)-estratrien-17-one-[2,4,6,7-³H]; Tritiated Estrone; Estrone-³H; E1-³H; Folliculin-[2,4,6,7-³H]; Ketohydroxyestratriene-[2,4,6,7-³H]
EINECS	Contact for details

Quality Control

Every batch of Estrone-[2,4,6,7-3H(N)] is manufactured and analyzed under controlled conditions to ensure radiochemical purity, specific activity, and chemical stability. Quality is verified by advanced techniques including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity (Ci/mmol or GBq/mmol), radiochemical purity, chemical purity, and solvent specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at or below -20°C in the original solvent as supplied. Store in accordance with all local and national regulations for radioactive materials. The product is easily oxidized; prolonged exposure to air should be avoided.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (HPLC)	Conforms to reference standard
Specific Activity	70-100 Ci/mmol (2.6-3.7 TBq/mmol)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solvent	Benzene:Ethanol (9:1) or as specified
Concentration	1.0 mCi/mL (37 MBq/mL) ± 10%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.