Description

1-[(2R,4S,5S)-4-Amino-5-(Hydroxymethyl)Oxolan-2-Yl]-5-Methylpyrimidine-2,4-Dione is a high-purity nucleoside derivative, a key chiral building block in advanced pharmaceutical synthesis. Its precise stereochemistry and functional groups make it an essential intermediate for the research and production of novel antiviral and anticancer therapeutics. This compound is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and CDMOs (Contract Development and Manufacturing Organizations) developing next-generation nucleoside analogs.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of novel antiviral drugs, including nucleoside reverse transcriptase inhibitors (NRTIs).
• Anticancer Agent Research: Serves as a building block for developing nucleoside-based chemotherapeutic agents targeting DNA/RNA synthesis.
• Biochemical Research: Used in enzymatic studies, metabolic pathway analysis, and as a substrate or inhibitor in molecular biology applications.
• Prodrug Development: Utilized in creating prodrug forms of nucleosides to enhance bioavailability and therapeutic efficacy.
• Fine Chemical Synthesis: Acts as a chiral synthon for the asymmetric synthesis of complex, biologically active molecules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory compliance in pharmaceutical manufacturing.

Basic Information

Product Name	1-[(2R,4S,5S)-4-Amino-5-(Hydroxymethyl)Oxolan-2-Yl]-5-Methylpyrimidine-2,4-Dione
CAS No.	52450-18-7
Molecular Formula	C10H15N3O5
Molecular Weight	257.24 g/mol
Synonyms	5-Methyl-2'-deoxycytidine; 5-Methyldeoxycytidine; 5-Methyl-dC; (2R,4S,5S)-4-Amino-5-(hydroxymethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran; 1-(4-Amino-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; m5dC; 5-Methyl-2'-deoxycytidine nucleoside
EINECS	Contact for details

Quality Control

Our 1-[(2R,4S,5S)-4-Amino-5-(Hydroxymethyl)Oxolan-2-Yl]-5-Methylpyrimidine-2,4-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral HPLC to confirm stereochemical integrity, ensuring compliance with research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and residual solvent levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2R,4S,5S)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.