Description

[2S-(2Alpha,4Alpha,5Alpha,6Beta)]-3,3-Dimethyl-7-Oxo-6-(Phenylacetamido)-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid 4-Oxide is a high-purity pharmaceutical intermediate and a key sulfoxide derivative in the penicillin family. This compound is of critical importance for its role in the synthesis and research of advanced β-lactam antibiotics, offering a precise chemical building block for complex molecular development. It is primarily needed by research institutions, pharmaceutical manufacturers, and fine chemical producers engaged in antibiotic development, process chemistry, and analytical reference standard preparation.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of specific penicillin and cephalosporin derivatives.
• Antibiotic Research & Development: Serves as a key reference compound and starting material for developing new β-lactam antibiotic candidates.
• Process Chemistry: Used in route scouting and optimization for the industrial-scale production of related antibiotic APIs.
• Analytical Standard: Employed as a high-purity reference standard in HPLC, LC-MS, and NMR for quality control and method validation.
• Biochemical Studies: Utilized in research to study the structure-activity relationships (SAR) and resistance mechanisms of β-lactam antibiotics.
• Fine Chemical Synthesis: Acts as a specialized building block for synthesizing complex, high-value molecules in medicinal chemistry.

Basic Information

Item	Details
Product Name	[2S-(2Alpha,4Alpha,5Alpha,6Beta)]-3,3-Dimethyl-7-Oxo-6-(Phenylacetamido)-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid 4-Oxide
CAS No.	52248-38-1
Molecular Formula	C16H18N2O5S
Molecular Weight	350.39 g/mol
Synonyms	Penicillin G Sulfoxide; 6-Phenylacetamidopenicillanic Acid Sulfoxide; Benzylpenicillin Sulfoxide; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-oxide; Ampicillin Sulfoxide Related Compound; Penicillin G 1-Oxide; 6-APA Sulfoxide Derivative
EINECS	Contact for details

Quality Control

Our [2S-(2Alpha,4Alpha,5Alpha,6Beta)]-3,3-Dimethyl-7-Oxo-6-(Phenylacetamido)-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid 4-Oxide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.