Description

(R)-(-)-Epichlorohydrin CAS NO 51594-55-9 is the single enantiomer form of epichlorohydrin, a versatile and highly reactive chiral building block. This optically pure compound is critical for introducing the (R)-glycidyl moiety into complex molecules, enabling the synthesis of enantiomerically pure pharmaceuticals and fine chemicals. It is essential for research and production in the pharmaceutical, agrochemical, and advanced materials sectors where stereochemical control is paramount.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key starting material for active pharmaceutical ingredients (APIs) requiring the (R)-glycidyl group, such as β-blockers and other cardiovascular drugs.
• Agrochemical Production: Used in the manufacture of enantiomerically pure herbicides, fungicides, and plant growth regulators for enhanced efficacy and environmental safety.
• Advanced Polymer & Resin Chemistry: Serves as a chiral monomer for producing specialty epoxy resins, adhesives, and coatings with tailored optical or mechanical properties.
• Liquid Crystal & Electronic Materials: Employed in the synthesis of chiral dopants for liquid crystal displays (LCDs) and other optoelectronic materials.
• Asymmetric Catalyst & Ligand Development: A valuable precursor for synthesizing chiral catalysts and ligands used in asymmetric hydrogenation and other stereoselective reactions.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic chemistry and process research for new chiral entities.

Basic Information

Product Name	(R)-(-)-Epichlorohydrin
CAS No.	51594-55-9
Molecular Formula	C3H5ClO
Molecular Weight	92.52 g/mol
Synonyms	(R)-(-)-1-Chloro-2,3-epoxypropane; (R)-(-)-Epichlorohydrin; (R)-(-)-Chloromethyloxirane; (R)-ECH; (R)-(-)-γ-Chloropropylene Oxide; (2R)-(-)-Epichlorohydrin; (R)-(-)-1-Epichlorohydrin; (R)-(-)-Epoxypropyl Chloride
EINECS	257-296-3

Quality Control

Our (R)-(-)-Epichlorohydrin is produced under stringent quality management systems to ensure batch-to-batch consistency and high optical purity. Each lot undergoes comprehensive analysis, including chiral HPLC for enantiomeric excess (ee) determination, to meet the exacting standards required for chiral synthesis. A Certificate of Analysis (COA) detailing purity, assay, and specific rotation is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong acids, bases, and oxidizing agents. Due to its highly volatile nature, keep containers tightly sealed. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]20/D	-30° to -34° (c=1 in CHCl3)
Water Content (KF)	≤ 0.1%
Density (20°C)	1.180 - 1.185 g/mL
Refractive Index (n20/D)	1.437 - 1.439

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.