Description

Glycopyrronium Bromide is a quaternary ammonium anticholinergic agent with significant pharmacological activity. This compound is a critical active pharmaceutical ingredient (API) valued for its potent and selective muscarinic receptor antagonism. It is primarily required by the pharmaceutical industry for the formulation of injectable solutions, inhalation products, and topical preparations used in the management of chronic obstructive pulmonary disease (COPD), excessive sweating (hyperhidrosis), and as a preoperative medication to reduce secretions.

Application

• Pharmaceutical API: Core ingredient in injectable formulations for preoperative use to inhibit salivary and bronchial secretions.
• Respiratory Therapeutics: Key component in dry powder inhalers (DPIs) and nebulizer solutions for the long-term management of chronic obstructive pulmonary disease (COPD).
• Antiperspirant Treatments: Used in topical solutions, wipes, and creams for the treatment of severe primary axillary hyperhidrosis (excessive sweating).
• Gastrointestinal Medications: Employed in formulations for reducing gastric acid secretion and managing gastrointestinal spasms.
• Ophthalmic Solutions: Utilized in eye drops for pupillary dilation (mydriasis) and cycloplegia during surgical procedures.
• Veterinary Medicine: Applied in veterinary practice for similar anticholinergic effects in animals.
• Research & Development: Serves as a reference standard and key intermediate in pharmacological research and new drug development.

Basic Information

Product Name	Glycopyrronium Bromide
CAS No.	51186-83-5
Molecular Formula	C19H28BrNO3
Molecular Weight	398.34 g/mol
Synonyms	Glycopyrrolate Bromide; Glycopyrrolate; 3-[(Cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethylpyrrolidinium Bromide; Robinul; AHR-504; Cuvposa; Seebri; NVA237; (3RS)-3-[(2SR)-2-Cyclopentyl-2-hydroxy-2-phenylacetoxy]-1,1-dimethylpyrrolidinium Bromide
EINECS	257-123-5

Quality Control

Our Glycopyrronium Bromide is manufactured under strict quality management systems. It is typically supplied to meet Pharmaceutical Grade standards, with specifications aligned with major pharmacopoeias such as USP, EP, and BP. Each batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and residual solvent analysis. Certificates of Analysis (COA) documenting purity, related substances, and other critical parameters are available upon request to ensure full traceability and compliance for your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.