Description

S(+)-Mianserin CAS NO 51152-88-6 is the pharmacologically active enantiomer of the tetracyclic antidepressant mianserin. This high-purity chiral compound is critical for advanced pharmaceutical research and development, particularly in neuropsychiatric drug discovery. It serves as a vital reference standard and a key intermediate for synthesizing novel therapeutic agents targeting specific serotonin and histamine receptors. Researchers and manufacturers in the pharmaceutical and biotechnology sectors rely on this enantiomer for its precise biological activity and role in developing more targeted and effective medications.

Application

• Primary use as a pharmaceutical reference standard for analytical method development and validation in QC/QA laboratories.
• Key chiral intermediate in the research and synthesis of novel antidepressant and anxiolytic drug candidates.
• Critical reagent in neuropharmacology studies investigating the mechanism of action of tetracyclic compounds at specific receptor sites.
• Active Pharmaceutical Ingredient (API) for preclinical and clinical research formulations focusing on enantiomer-specific effects.
• Building block for medicinal chemistry programs aimed at creating new chemical entities with improved selectivity and reduced side-effect profiles.
• Component in analytical testing kits and diagnostic assays for pharmacological research.

Basic Information

Product Name	S(+)-Mianserin
CAS No.	51152-88-6
Molecular Formula	C18H20N2
Molecular Weight	264.37 g/mol
Synonyms	(+)-Mianserin; (S)-Mianserin; (S)-(+)-1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine; S(+)-1,2,3,4,10,14b-Hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepine; (S)-1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine; Dexmianserin; Levomianserin (Note: often used interchangeably but verify stereochemistry)
EINECS	Contact for details

Quality Control

Our S(+)-Mianserin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to confirm identity, potency, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with cGMP and ISO guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.