Description

O(6)-Ethyl-2'-Deoxyguanosine is a chemically modified nucleoside analog of deoxyguanosine, where an ethyl group is specifically attached to the O6 position of the guanine base. This structural modification makes it a critical reference standard and research tool for studying DNA alkylation damage, mutagenesis, and repair mechanisms. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors focused on oncology, toxicology, and molecular biology.

Application

• Biochemical Research: Used as a key reference standard in studies of DNA adduct formation, repair enzyme activity (e.g., O6-alkylguanine-DNA alkyltransferase), and mutagenic pathways.
• Pharmaceutical Development: Serves as a critical impurity standard and metabolite marker in the development and quality control of alkylating chemotherapeutic agents.
• Toxicology & Safety Assessment: Employed as a biomarker in analytical assays to quantify exposure to alkylating agents and assess genotoxic risk.
• Diagnostic Kit Manufacturing: Incorporated into diagnostic kits and assays designed to detect DNA damage and repair capacity in clinical and research settings.
• Academic Research: Fundamental tool for investigating the structural and functional consequences of specific DNA lesions in model systems.

Basic Information

Product Name	O(6)-Ethyl-2'-Deoxyguanosine
CAS No.	50704-46-6
Molecular Formula	C12H17N5O4
Molecular Weight	295.29 g/mol
Synonyms	O6-Ethyldeoxyguanosine; 2'-Deoxy-O6-ethylguanosine; O6-Et-dG; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-ethyl-1H-purin-2-one; 6-Ethoxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)guanine; dG-O6Et; O6-alkylguanine DNA adduct standard
EINECS	Contact for details

Quality Control

Every batch of O(6)-Ethyl-2'-Deoxyguanosine is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical documentation, including HPLC chromatograms and spectroscopic data (NMR, MS), to verify identity and purity. A Certificate of Analysis (COA) detailing batch-specific results is available for each shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container should be equilibrated to room temperature before opening to prevent condensation. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.