Description

Mizoribine CAS NO 50524-49-7 is a synthetic nucleoside analog with potent immunosuppressive activity. It serves as a critical active pharmaceutical ingredient (API) for the formulation of immunosuppressant drugs, primarily used to prevent organ transplant rejection and treat autoimmune diseases. This high-purity compound is essential for pharmaceutical manufacturers and research institutions developing targeted immunomodulatory therapies.

Application

• Primary Pharmaceutical Ingredient: Core API in immunosuppressant medications for kidney transplant patients.
• Autoimmune Disease Treatment: Research and development of therapies for conditions like lupus nephritis and rheumatoid arthritis.
• Clinical Research: Used as a reference standard and active compound in immunological and pharmacological studies.
• Drug Formulation: Serves as the key component in the production of tablets, capsules, and injectable formulations.
• Mechanistic Studies: Tool for investigating inosine monophosphate dehydrogenase (IMPDH) inhibition and purine biosynthesis pathways.

Basic Information

Product Name	Mizoribine
CAS No.	50524-49-7
Molecular Formula	C9H13N3O6
Molecular Weight	259.22 g/mol
Synonyms	4-Carbamoyl-1-β-D-ribofuranosylimidazolium-5-olate; Bredinin; MZR; Mycophenolate mofetil analog; 1-β-D-Ribofuranosyl-1H-imidazole-4-carboxamide 5-oxide; 4-Carbamoyl-1-β-D-ribofuranosylimidazolium-5-olate; 1H-Imidazole-4-carboxamide, 1-β-D-ribofuranosyl-, 5-oxide
EINECS	Contact for details

Quality Control

Our Mizoribine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR, and stringent control of related substances and residual solvents, ensuring compliance with pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.