Description

2-Pyrrolidinone, [5-14C] is a carbon-14 labeled derivative of 2-pyrrolidinone, a versatile lactam solvent and chemical intermediate. This radiolabeled compound is essential for conducting precise metabolic, pharmacokinetic, and environmental fate studies, providing critical data on the absorption, distribution, metabolism, and excretion (ADME) of related compounds. It is primarily utilized by researchers and scientists in the pharmaceutical, agrochemical, and life science industries who require high-specific-activity tracers for advanced analytical applications.

Application

• Tracer in ADME Studies: Used as a radiolabeled tracer to investigate the metabolic pathways and pharmacokinetic profiles of pharmaceuticals and agrochemicals containing the 2-pyrrolidinone moiety.
• Metabolic Pathway Elucidation: Enables the detailed mapping of biotransformation routes in in vitro and in vivo systems for safety and efficacy evaluations.
• Environmental Fate Studies: Applied in research to track the degradation, persistence, and mobility of chemical compounds in environmental matrices.
• Biochemical Research: Serves as a labeled precursor or intermediate in the synthesis of more complex radiolabeled molecules for biological testing.
• Analytical Method Development: Used as a standard in Liquid Scintillation Counting (LSC) and accelerator mass spectrometry (AMS) for calibrating detection systems and validating analytical methods.
• Mechanistic Studies: Facilitates research into chemical reaction mechanisms and polymer science where tracking specific carbon atoms is required.

Basic Information

Item	Detail
Product Name	2-Pyrrolidinone, [5-14C]
CAS No.	50494-55-8
Molecular Formula	C4H714CONH
Molecular Weight	~86.11 g/mol (calculated with 14C)
Synonyms	2-Pyrrolidone-5-14C; γ-Butyrolactam-5-14C; 2-Oxopyrrolidine-5-14C; 2-Pyrrolidinone-5-carbon-14; 4-Aminobutyric acid lactam-5-14C; Butyrolactam-5-14C; NSC 66418-5-14C
EINECS	Contact for details

Quality Control

Every batch of 2-Pyrrolidinone, [5-14C] is produced and analyzed under strict quality protocols to ensure high chemical and radiochemical purity, specific activity, and stability. Comprehensive testing includes verification by spectroscopic methods and chromatographic analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the specific activity, radiochemical purity, chemical purity, and solvent composition. Our quality system is designed to meet the stringent requirements of research and regulatory applications.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures, typically between 2°C and 8°C or as specified on the label, to maintain stability and specific activity. The product is light-sensitive (store away from light). Keep the container in a well-ventilated area and handle with appropriate precautions for radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (IR/NMR)	Conforms to structure
Chemical Purity (HPLC)	≥ 98%
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	Customized (mCi/mmol)
Solvent	Specified (e.g., Ethanol, Toluene)
Concentration	Specified (mCi/mL or mg/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.