Description

Chaetoglobosin A is a potent cytochalasan alkaloid mycotoxin, primarily known for its distinctive biological activity as an inhibitor of actin polymerization and microtubule assembly. This unique mode of action makes it a highly valuable reference standard and research biochemical for studying cytoskeletal dynamics, cell division, and cellular morphology. It is essential for researchers and developers in pharmaceutical discovery, cell biology, and toxicology, providing critical insights into fundamental cellular processes and potential therapeutic pathways.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active probe in drug discovery programs targeting the cytoskeleton, cancer cell motility, and metastasis.
• Cell Biology Studies: A critical tool for investigating actin filament dynamics, cytokinesis, and cellular shape changes in vitro.
• Biochemical Research: Serves as a specific inhibitor in mechanistic studies of myosin function and other actin-dependent processes.
• Toxicology & Safety Assessment: Employed as an analytical standard for the detection and quantification of mycotoxins in food, feed, and environmental samples.
• Academic Research: Fundamental research reagent in universities and institutes for studies in molecular biology, pharmacology, and mycology.
• Quality Control Laboratories: Used as a certified reference material (CRM) to validate analytical methods like HPLC and LC-MS in testing labs.

Basic Information

Product Name	Chaetoglobosin A
CAS No.	50335-03-0
Molecular Formula	C32H36N2O5
Molecular Weight	528.64 g/mol
Synonyms	Chaetoglobosin A; NSC 332836; 19-O-Acetylchaetoglobosin B; [1aS-(1aα,4E,10bα,11aα)]-1a,2,3,4,5,6,10b,11,11a,12-Decahydro-11a-hydroxy-1a-methyl-10b-[[2-methyl-1-oxo-2-butenyl]oxy]-8H-10-oxa-2-azacyclopenta[cd]phenalen-8-one; Mycotoxin from Chaetomium globosum
EINECS	Contact for details

Quality Control

Our Chaetoglobosin A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with ISO 17034 guidelines for reference material producers, and our analytical methods are validated to meet the exacting standards of the global research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the vial to equilibrate to room temperature in a dry atmosphere before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.