Description

Isopilocarpine Nitrate is a high-purity pharmaceutical-grade salt of the alkaloid isopilocarpine, identified by CAS NO 5984-94-1. This compound is a critical intermediate and reference standard in the research and development of cholinergic agents, primarily due to its structural similarity to pilocarpine. It is essential for pharmaceutical manufacturers, research institutions, and analytical laboratories engaged in ophthalmic drug development, neuropharmacology studies, and quality control processes. Our supply ensures consistent quality and reliable availability for your most demanding applications.

Application

• Pharmaceutical Intermediate: Serves as a key starting material or intermediate in the synthesis of specialized cholinergic drugs and active pharmaceutical ingredients (APIs).
• Research & Development: Used as a reference standard and biochemical tool in pharmacological studies targeting muscarinic acetylcholine receptors.
• Ophthalmic Research: Investigated for potential applications in glaucoma research and the development of miotic agents, given its structural relation to pilocarpine.
• Analytical Standard: Employed in high-performance liquid chromatography (HPLC) and other analytical methods for system suitability testing, method development, and quality assurance.
• Chemical Synthesis: Utilized in organic synthesis for creating novel derivatives with potential therapeutic activity.

Basic Information

Item	Details
Product Name	Isopilocarpine Nitrate
CAS No.	5984-94-1
Molecular Formula	C11H17N3O5
Molecular Weight	271.27 g/mol
Synonyms	Isopilocarpine Mononitrate; (3S,4R)-3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]oxolan-2-one Nitrate; Pilocarpine Isomer Nitrate; 5,6-Dihydro-6-[(1-methyl-1H-imidazol-5-yl)methyl]-4H-imidazo[1,5-a]thieno[3,2-f][1,4]diazepin-4-one Nitrate (related isomer); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Isopilocarpine Nitrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets exacting standards for pharmaceutical research. A Certificate of Analysis (COA) detailing specific results for purity (typically ≥98% by HPLC), residual solvents, and related substances is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep away from strong oxidizing agents. The product is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.