Description

Hydroxymethyldiphenylphosphine is a versatile organophosphorus compound featuring both a phosphine and a hydroxymethyl functional group. This bifunctional structure makes it a valuable intermediate and ligand in advanced chemical synthesis, particularly for applications requiring precise molecular control. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries. Its reactivity profile enables its use in catalysis and as a building block for more complex phosphorus-containing molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing phosphorus.
• Catalyst Ligand: Acts as a ligand in transition metal catalysis for cross-coupling reactions, hydrogenation, and other organometallic processes.
• Agrochemical Synthesis: Used in the development of herbicides, insecticides, and plant growth regulators that incorporate phosphine or phosphonate groups.
• Material Science: Employed in the creation of flame retardants, stabilizers for polymers, and precursors for advanced materials.
• Organic Synthesis Building Block: Utilized in academic and industrial R&D for constructing complex molecules via reactions at the phosphine or alcohol sites.
• Ligand for Asymmetric Catalysis: Its structure can be modified to create chiral ligands for enantioselective synthesis.

Basic Information

Product Name	Hydroxymethyldiphenylphosphine
CAS No.	5958-44-1
Molecular Formula	C13H13OP
Molecular Weight	216.22 g/mol
Synonyms	(Hydroxymethyl)diphenylphosphine; Diphenyl(hydroxymethyl)phosphine; (Diphenylphosphino)methanol; α-Hydroxybenzhydrylphosphine; HMPP; Phosphine, (hydroxymethyl)diphenyl-; NSC 163083
EINECS	227-732-5

Quality Control

Our Hydroxymethyldiphenylphosphine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We adhere to relevant ISO guidelines and can support compliance documentation for cGMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, the container should be purged with inert gas after each opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.