Description

Ethyl (2S)-Pyrrolidine-2-Carboxylate is a high-purity chiral building block and ester derivative of L-proline. This compound is valued for its role as a key intermediate in the synthesis of complex pharmaceuticals and bioactive molecules, enabling the introduction of a defined stereocenter. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of protease inhibitors, antiviral drugs, and other active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides with specific stereochemical requirements.
• Peptidomimetics & Drug Discovery: Serves as a constrained proline analog in the design of novel peptide-based therapeutics and diagnostic agents.
• Asymmetric Catalysis: Employed as a precursor for chiral ligands and organocatalysts used in stereoselective chemical transformations.
• Fine Chemical Production: A building block for specialty chemicals, flavors, fragrances, and advanced material precursors.
• Academic & Industrial R&D: A standard reagent in medicinal chemistry and organic synthesis laboratories for method development and compound library generation.

Basic Information

Product Name	Ethyl (2S)-Pyrrolidine-2-Carboxylate
CAS No.	5817-26-5
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	L-Proline ethyl ester; (S)-(-)-Proline ethyl ester; Ethyl L-prolinate; Ethyl (S)-(-)-2-pyrrolidinecarboxylate; (2S)-2-Pyrrolidinecarboxylic acid ethyl ester; (-)-Proline ethyl ester; L-Prolinol, 2-ethoxycarbonyl-; Proline ethyl ester hydrochloride (salt form)
EINECS	227-380-6

Quality Control

Our Ethyl (2S)-Pyrrolidine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee consistent quality, identity, and purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]20/D	-70° to -80° (c=1 in EtOH)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.