Description

Phenylthiohydantoin-Tryptophan (CAS NO 5789-24-2) is a specialized derivative of tryptophan, a crucial amino acid, formed via the Edman degradation reaction. This compound is of significant value in analytical biochemistry and peptide research for the precise sequencing and identification of proteins. It is primarily utilized by research institutions, pharmaceutical development labs, and diagnostic manufacturers requiring high-purity biochemical reagents.

Application

• Protein Sequencing & Peptide Analysis: A key intermediate in the Edman degradation process for stepwise N-terminal amino acid analysis.
• Biochemical Research Reagent: Used in academic and industrial laboratories for studying protein structure, function, and post-translational modifications.
• Pharmaceutical Development: Serves as a reference standard and building block in the development of peptide-based therapeutics and diagnostic assays.
• Proteomics & Mass Spectrometry: Employed as a standard for calibration and method development in advanced analytical techniques like HPLC-MS.
• Quality Control in Biomanufacturing: Used to verify the sequence and purity of synthetic peptides and recombinant proteins.

Basic Information

Product Name	Phenylthiohydantoin-Tryptophan
CAS No.	5789-24-2
Molecular Formula	C₁₉H₁₇N₃O₂S
Molecular Weight	351.42 g/mol
Synonyms	PTH-Tryptophan; 3-[(Phenylamino)(thioxo)methyl]-1H-indole-2-carboxylic acid; PTH-Trp; Edman Degradation Product of Tryptophan; 2-Carboxy-3-(phenylthiocarbamoyl)indole; Phenylthiocarbamoyltryptophan; 1H-Indole-2-carboxylic acid, 3-[(phenylamino)thioxomethyl]-; Tryptophan phenylthiohydantoin
EINECS	Contact for details

Quality Control

Our Phenylthiohydantoin-Tryptophan is manufactured under strict quality protocols suitable for research and analytical applications. Each batch is tested to ensure high purity and consistency, with specifications typically meeting or exceeding standard biochemical reagent grades. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), and related substance profiles is provided with every shipment to ensure full traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.