Description

Fluorosulfuric Trifluoroacetic Anhydride is a highly reactive acylating and sulfonating agent formed from fluorosulfuric acid and trifluoroacetic anhydride. This compound is a powerful reagent for introducing the fluorosulfonyl group, a key moiety in the synthesis of sulfonyl fluorides, which are critical building blocks in modern drug discovery and materials science. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds and advanced functional materials.

Application

• Sulfonyl Fluoride Synthesis: A key reagent for the efficient preparation of sulfonyl fluorides (R-SO₂F) via reactions with organometallic reagents or arenes, essential for SuFEx (Sulfur(VI) Fluoride Exchange) click chemistry.
• Pharmaceutical Intermediates: Used in the synthesis of active pharmaceutical ingredients (APIs) and complex intermediates, particularly those requiring sulfonamide or sulfonate ester functional groups.
• Agrochemical Development: Employed in creating novel herbicides, fungicides, and insecticides where the sulfonyl fluoride group impributes specific biological activity or acts as a synthetic handle.
• Polymer & Materials Science: Serves as a monomer or modifying agent for producing specialty polymers with enhanced thermal stability, chemical resistance, or specific surface properties.
• Chemical Research & Process Development: A versatile tool in academic and industrial R&D labs for exploring new synthetic methodologies and developing scalable routes to target molecules.
• Fluorination Reactions: Acts as a source of electrophilic fluorine or as a promoter in specific fluorination transformations.

Basic Information

Product Name	Fluorosulfuric Trifluoroacetic Anhydride
CAS No.	5762-53-8
Molecular Formula	C4F4O4S
Molecular Weight	212.09 g/mol
Synonyms	Trifluoroacetic Fluorosulfuric Anhydride; Fluorosulfonic Trifluoroacetic Anhydride; Trifluoroacetyl Fluorosulfonate; FSO2OCOCF3; Fluorosulfonyl Trifluoroacetate; (Trifluoroacetyloxy)sulfonyl Fluoride; Bis(trifluoroacetyl) Sulfate (related); F-TFAA
EINECS	227-274-6

Quality Control

Our Fluorosulfuric Trifluoroacetic Anhydride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot is analyzed using advanced techniques including NMR, IR, and titration to confirm identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, moisture content, and other critical parameters is provided with every shipment to support your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and a strong acid/organic solvent; ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain purity and prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 98.0 %
Water Content (KF)	≤ 0.5 %
NMR Purity (19F, 1H)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.