Description

Ne-Carboxymethyl-L-Lysine is a chemically modified amino acid derivative, specifically a carboxymethylated form of L-lysine. This compound is of significant interest in biochemical research and advanced material synthesis due to its unique bifunctional structure, featuring both a free amino group and a carboxylic acid group. It serves as a critical intermediate and building block for researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors who require high-purity, well-characterized specialty chemicals for peptide synthesis, cross-linking applications, and the development of advanced glycation end-product (AGE) studies.

Application

• Biochemical Research: A key reagent in the study of Advanced Glycation End-products (AGEs), particularly as a standard or hapten in immunoassays and analytical methods.
• Pharmaceutical Intermediates: Serves as a specialized building block for the synthesis of novel peptide-based drugs and bioactive compounds.
• Diagnostic Development: Used in the production of antibodies, ELISA kits, and other diagnostic tools for detecting glycation markers related to diabetes and aging.
• Cross-linking Agent: Its bifunctional nature allows it to act as a spacer or cross-linker in bioconjugation and material surface modification.
• Life Science Reagents: Employed in cell culture media research and as a component in studies of metabolic pathways involving lysine modification.
• Reference Standard: Provides a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.

Basic Information

Product Name	Ne-Carboxymethyl-L-Lysine
CAS No.	5746-04-3
Molecular Formula	C8H16N2O4
Molecular Weight	204.22 g/mol
Synonyms	Nε-Carboxymethyl-L-lysine; CML; N6-Carboxymethyl-L-lysine; (2S)-2-Amino-6-[(carboxymethyl)amino]hexanoic acid; Ne-(Carboxymethyl)-L-lysine; L-Lysine, N6-(carboxymethyl)-; AGE-CML; Advanced Glycation Endproduct CML
EINECS	227-270-6

Quality Control

Our Ne-Carboxymethyl-L-Lysine is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	+15.0° to +20.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.