Description

Desmethylmaprotiline is a key pharmaceutical intermediate and metabolite of the tricyclic antidepressant maprotiline. This compound is of significant value in the research and development of neuropharmacological agents, serving as a critical reference standard and building block. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism studies, pharmacokinetic research, and the synthesis of novel therapeutic compounds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of maprotiline and related tricyclic antidepressant compounds.
• Reference Standard: Used as a certified reference material (CRM) in analytical chemistry for method development, validation, and quality control testing of active pharmaceutical ingredients (APIs).
• Metabolite Studies: Essential for in-vitro and in-vivo drug metabolism and pharmacokinetics (DMPK) research to understand the biotransformation pathways of maprotiline.
• Biochemical Research: Employed in neuroscience research to study the mechanism of action, receptor binding affinity, and structure-activity relationships (SAR) of noradrenaline reuptake inhibitors.
• Impurity Profiling: Serves as a known impurity standard to monitor and control the quality of maprotiline API during manufacturing, ensuring compliance with ICH guidelines.

Basic Information

Product Name	Desmethylmaprotiline
CAS No.	5721-37-9
Molecular Formula	C19H21N
Molecular Weight	263.38 g/mol
Synonyms	N-Desmethylmaprotiline; 3-(9,10-Dihydro-9,10-ethanoanthracen-9-yl)methyl]methylamine; 1-(3-Methylaminopropyl)dibenzo[b,e]bicyclo[2.2.2]octadiene; Maprotiline Desmethyl Metabolite; Desmethyl Maprotiline; Nor-Maprotiline; Ludomil Metabolite
EINECS	Contact for details

Quality Control

Our Desmethylmaprotiline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.