Description

Pth-L-Glutamic Acid CAS NO 5624-27-1 is a protected derivative of the essential amino acid L-glutamic acid, where the amine group is shielded by a phthaloyl (Pth) group. This modification is critical for enabling selective peptide synthesis and advanced biochemical research where precise control over amino acid reactivity is required. It is an indispensable building block for pharmaceutical R&D, peptide chemists, and biotechnology companies developing novel therapeutic agents and diagnostic tools.

Application

• Peptide Synthesis: Serves as a key protected intermediate in solid-phase and solution-phase peptide synthesis (SPPS), preventing unwanted side reactions.
• Pharmaceutical Intermediates: Used in the research and development of peptide-based drugs, hormones, and other bioactive compounds.
• Biochemical Research: Employed in studies of enzyme mechanisms, receptor-ligand interactions, and metabolic pathways involving glutamic acid.
• Protecting Group Chemistry: Acts as a model compound for studying the introduction and removal of phthaloyl protecting groups under various conditions.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for HPLC and other chromatographic methods.

Basic Information

Product Name	Pth-L-Glutamic Acid
CAS No.	5624-27-1
Molecular Formula	C₁₃H₁₁NO₆
Molecular Weight	277.23 g/mol
Synonyms	N-Phthaloyl-L-glutamic Acid; (S)-2-(1,3-Dioxoisoindolin-2-yl)pentanedioic Acid; L-Glutamic Acid N-Phthalimide; Pth-Glu-OH; N-Pth-L-glutamic Acid; Phthaloyl-L-glutamic Acid; 2-[(S)-1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl]pentanedioic Acid
EINECS	227-058-8

Quality Control

Our Pth-L-Glutamic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identity confirmation by IR and NMR, purity assessment by HPLC, and specific tests for optical rotation and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-20.0° to -24.0° (c=1 in DMF)
Loss on Drying	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.