Description

9-Methylguanine is a methylated purine derivative and a key modified nucleobase used extensively in biochemical research. This compound is crucial for studying DNA alkylation damage, repair mechanisms, and epigenetic modifications. It serves as a vital reference standard and building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors.

Application

• Biochemical Research Standard: Used as a high-purity analytical standard for the quantification and study of DNA methylation and damage products.
• Nucleic Acid Chemistry: Acts as a key intermediate in the synthesis of modified oligonucleotides for therapeutic and diagnostic applications.
• Enzyme Substrate Studies: Employed in assays to study the activity of DNA repair enzymes, such as alkylguanine-DNA alkyltransferases.
• Cancer Research: Investigated for its role in mutagenesis and as a biomarker for exposure to alkylating agents.
• Pharmaceutical Development: Utilized in the research and development of novel chemotherapeutic agents and targeted therapies.
• Academic Research: A fundamental tool in universities and research institutes for exploring nucleic acid structure, function, and repair pathways.

Basic Information

Product Name	9-Methylguanine
CAS No.	5502-78-3
Molecular Formula	C6H7N5O
Molecular Weight	165.15 g/mol
Synonyms	N9-Methylguanine; Guan-9-ine, 9-methyl-; 9-Methyl-1H-purin-6-amine; 2-Amino-9-methyl-1,9-dihydro-6H-purin-6-one; 2-Amino-9-methyl-6-hydroxypurine; 9-Methylguanine; N-Methylguanine; 1,9-Dihydro-9-methyl-6H-purin-6-one, 2-amino-
EINECS	226-842-9

Quality Control

Our 9-Methylguanine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.