Description

2-(2-Chloropurin-9-Yl)-5-(Hydroxymethyl)Oxolane-3,4-Diol is a key nucleoside analog building block, specifically a chlorinated derivative of guanosine. This compound is valued for its role as a versatile synthetic intermediate in the development of novel pharmaceutical agents and biochemical probes. It is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral, anticancer, and nucleotide-based therapeutic discovery.

Application

• Pharmaceutical Intermediate: Critical starting material for the synthesis of nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and polymerase function.
• Pro-drug Development: Serves as a precursor for creating more bioavailable or targeted forms of active nucleoside compounds.
• Antisense Oligonucleotide Synthesis: A building block for modified oligonucleotides used in genetic research and therapeutic applications.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	2-(2-Chloropurin-9-Yl)-5-(Hydroxymethyl)Oxolane-3,4-Diol
CAS No.	5466-11-5
Molecular Formula	C10H11ClN4O4
Molecular Weight	286.67 g/mol
Synonyms	2-Chloro-2'-deoxyguanosine; 2-Chloro-2'-deoxy-Guanosine; 2-Chloro-9-(2-deoxy-β-D-erythro-pentofuranosyl)guanine; 2-Chloro-2'-deoxy-β-D-guanosine; 2-Cl-dG; 2-Chloro-2'-deoxyguanosine (2-Cl-dG); 2'-Deoxy-2-chloroguanosine
EINECS	Contact for details

Quality Control

Our 2-(2-Chloropurin-9-Yl)-5-(Hydroxymethyl)Oxolane-3,4-Diol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.