Description

β-Acetyldigoxin is a semi-synthetic cardiac glycoside derivative, specifically an acetylated form of digoxin. This compound is of significant interest in pharmaceutical research and development for its potential to modulate cardiac contractility and heart rate. It is primarily utilized by research institutions and pharmaceutical companies engaged in cardiovascular drug discovery and the synthesis of novel therapeutic agents. The material is supplied as a high-purity reference standard and intermediate for advanced chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel cardiac glycoside derivatives and related therapeutic compounds.
• Biochemical Research: Used as a reference standard and probe in studies investigating the mechanism of action of Na+/K+-ATPase inhibition.
• Cardiovascular Drug Development: Serves as a precursor or model compound in the discovery of new agents for treating heart failure and arrhythmias.
• Analytical Standard: Employed as a certified reference material (CRM) for quality control and method validation in HPLC and LC-MS analysis within pharmaceutical laboratories.
• Metabolite Studies: Used in pharmacokinetic and metabolic pathway research related to digoxin and other cardiac glycosides.

Basic Information

Product Name	β-Acetyldigoxin
CAS No.	5355-48-6
Molecular Formula	C₄₃H₆₆O₁₅
Molecular Weight	822.97 g/mol
Synonyms	β-Acetyldigoxin; 3''-O-Acetyldigoxin; Acetyldigoxin; 16β-Acetylgitoxin; 3''-Acetyldigoxin; 12β-Acetyldigoxin; Digoxin 3''-acetate; (3β,5β,12β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide 3-acetate
EINECS	226-311-6

Quality Control

Our β-Acetyldigoxin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.