Description

Adenine-8-14C is a carbon-14 labeled isotopologue of adenine, a fundamental purine base. This radiolabeled compound is essential for conducting precise metabolic and pharmacokinetic tracer studies in biochemical research. It is primarily used by researchers and scientists in the pharmaceutical, biotechnology, and life sciences sectors for drug development and molecular biology applications.

Application

• Tracer Studies in Drug Metabolism and Pharmacokinetics (DMPK): Used to track the absorption, distribution, metabolism, and excretion (ADME) of novel drug candidates.
• Nucleic Acid Research: Employed in the study of DNA/RNA synthesis, repair mechanisms, and nucleotide metabolism pathways.
• Biochemical Pathway Analysis: Facilitates the elucidation of purine salvage and de novo synthesis pathways in cellular systems.
• Enzyme Kinetics and Mechanism Studies: Serves as a labeled substrate for investigating the activity and inhibition of enzymes like adenosine deaminase.
• Autoradiography and Imaging: Provides a radioactive tag for visualizing nucleotide incorporation in tissues or cellular fractions.
• Quality Control for Radiopharmaceuticals: Acts as a reference standard in the production and testing of labeled diagnostic agents.

Basic Information

Product Name	Adenine-8-14C
CAS No.	5019-49-8
Molecular Formula	C5[14C]H5N5
Molecular Weight	~136.1 g/mol (exact mass depends on specific activity)
Synonyms	6-Aminopurine-8-14C; Vitamin B4-8-14C; 1H-Purin-6-amine-8-14C; [8-14C]Adenine; 9H-Purin-6-amine-8-14C; Adenine-8-14C (labeled); 14C-Adenine
EINECS	Contact for details

Quality Control

Our Adenine-8-14C is produced and handled under strict quality protocols. Each batch is characterized for critical parameters including radiochemical purity, specific activity, and chemical purity using advanced analytical techniques. Certificates of Analysis (COA) detailing the results of HPLC, NMR, and mass spectrometry analyses are provided to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric moisture. For long-term storage, consider conditions recommended for radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for specific value)
Solvent (for solutions)	Specified on COA (e.g., Ethanol:Water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.