Description

Urea, [14C] CAS NO 594-05-8 is a carbon-14 radiolabeled isotopologue of urea, a fundamental organic compound. This labeled version is essential for precise metabolic and pharmacokinetic studies, enabling researchers to track the fate of urea and related nitrogenous compounds in complex biological and chemical systems. It is a critical tool for scientists in pharmaceutical research, agricultural chemistry, and environmental science who require definitive tracing of metabolic pathways.

Application

• Tracer Studies in Metabolism: Used to investigate the urea cycle, nitrogen excretion, and protein catabolism in vivo and in vitro.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed as a radiolabeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) of new chemical entities and prodrugs.
• Agricultural Research: Tracks the uptake, translocation, and metabolism of urea-based fertilizers and nitrification inhibitors in plants and soil systems.
• Environmental Fate Studies: Monitors the degradation, persistence, and transformation pathways of urea and its derivatives in environmental matrices.
• Biochemical Pathway Analysis: Serves as a precursor for studying purine and pyrimidine biosynthesis and other nitrogen incorporation pathways.
• Diagnostic Agent Development: Used in the research and development of diagnostic tests, such as breath tests for Helicobacter pylori infection (¹⁴C-Urea Breath Test).

Basic Information

Product Name	Urea, [14C]
CAS No.	594-05-8
Molecular Formula	CH4¹⁴CN2O
Molecular Weight	62.06 g/mol (nominal, for ¹⁴C-labeled)
Synonyms	Carbamide-¹⁴C; Carbon-14 Labeled Urea; [¹⁴C]Urea; Urea-¹⁴C; ¹⁴C-Urea; Isotopic Urea; Radiolabeled Urea; Urea (carbon-14 labeled)
EINECS	209-821-2 (for unlabeled urea)

Quality Control

Every batch of Urea, [14C] is produced and analyzed under strict quality systems to ensure radiochemical purity, chemical purity, and specific activity meet the stringent requirements of research applications. Identity is confirmed by spectroscopic methods (IR, NMR), and purity is assessed via HPLC or TLC. A comprehensive Certificate of Analysis (COA) detailing the specific activity (mCi/mmol or GBq/mmol), radiochemical purity (typically >97%), chemical purity, and solvent composition is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture ingress. For long-term storage, keep containers in a dedicated, well-ventilated freezer designated for radiochemicals. Follow all applicable local and national regulations for the storage of radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (IR/NMR)	Conforms to structure
Specific Activity	Customizable (e.g., 50-60 mCi/mmol)
Radiochemical Purity (HPLC/TLC)	≥ 97%
Chemical Purity (HPLC)	≥ 98%
Solvent (if supplied as solution)	Ethanol, Water, or as specified
Concentration (if supplied as solution)	Customizable (e.g., 1.0 mCi/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.