Description

Physostigmine is a parasympathomimetic alkaloid, primarily known for its potent reversible acetylcholinesterase inhibitor activity. This mechanism is critical for modulating cholinergic neurotransmission, making it a compound of significant pharmacological and research interest. It is essential for pharmaceutical development, biochemical research, and as a reference standard in analytical laboratories. The product is supplied as Physostigmine CAS NO 57-47-6, meeting high-purity standards for professional use.

Application

• Pharmaceutical Active Ingredient (API): Used in the formulation of ophthalmic solutions for the treatment of glaucoma and to reverse the effects of certain toxins and drugs.
• Biochemical Research: Serves as a critical tool compound in neuroscience and pharmacology studies to investigate cholinergic systems and enzyme kinetics.
• Reference Standard: Employed in quality control laboratories for the identification and assay of physostigmine in drug substances and finished products via HPLC, GC, or titration methods.
• Chemical Synthesis: Acts as a key chiral building block or intermediate in the synthesis of more complex pharmaceutical agents and analogs.

Basic Information

Product Name	Physostigmine
CAS No.	57-47-6
Molecular Formula	C15H21N3O2
Molecular Weight	275.35 g/mol
Synonyms	Eserine; Physostol; Eserine salicylate (salt precursor); (3aR,8aS)-1,3a,8-Trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl methylcarbamate; Calabarine; Fisostigmina; Physostigmine base
EINECS	200-334-3

Quality Control

Our Physostigmine is manufactured and tested under a strict quality management system. Each batch is analyzed to ensure it meets stringent specifications for identity, purity, and potency, suitable for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing all test results, including assay by HPLC and related substance profiles, is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its properties of being light-sensitive (store away from light) and easily oxidized (store under inert atmosphere), it is recommended to handle under an inert atmosphere such as nitrogen for long-term storage and to minimize headspace in opened containers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.