Description

Glycine, [1-14C] CAS NO 56-39-3 is a carbon-14 labeled isotopologue of the fundamental amino acid glycine, where the carbon atom at the 1-position is the radioactive isotope 14C. This product is essential for tracer studies and metabolic research, enabling scientists to track biochemical pathways with high precision. It is primarily used by researchers and manufacturers in the pharmaceutical, agrochemical, and life science sectors for drug metabolism studies, protein labeling, and investigative biochemistry.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of new drug candidates.
• Biochemical Pathway Analysis: Tracks the incorporation and fate of glycine in metabolic cycles, such as the synthesis of purines, glutathione, and creatine.
• Protein and Peptide Labeling: Serves as a building block for the biosynthesis of radiolabeled proteins and peptides for structural and functional studies.
• Agrochemical Research: Employed in studies to understand the metabolism and environmental fate of herbicides and pesticides in plants.
• Medical Diagnostic Research: Aids in the development of novel diagnostic agents and imaging probes.
• Quality Control Reference Standard: Acts as an internal standard in analytical methods like LC-MS for quantitative analysis in complex matrices.

Basic Information

Product Name	Glycine, [1-14C]
CAS No.	56-39-3
Molecular Formula	C14CH5NO2 / C2H5NO2 (unlabeled)
Molecular Weight	~76.05 g/mol (exact mass depends on specific activity)
Synonyms	[1-14C]Glycine; Aminoacetic-1-14C acid; Glycine-1-14C; 2-Amino[1-14C]acetic acid; NSC 20268; Glycocoll; Gly; Aminoethanoic acid-1-14C
EINECS	200-272-2 (for unlabeled glycine)

Quality Control

Every batch of our Glycine, [1-14C] is produced and tested under stringent conditions to ensure high radiochemical purity and specific activity. Quality is verified through advanced analytical techniques including HPLC and radio-HPLC. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity, radiochemical purity, chemical purity, and solvent content. Our quality system supports compliance with cGMP for investigational use in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider conditions recommended for radioactive materials. Keep away from strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Specific Activity	Contact for details (mCi/mmol)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 98%
Solvent (Residual)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.