Description

(+)-Pilocarpine Hydrochloride CAS NO 54-71-7 is a high-purity, pharmaceutically active alkaloid salt derived from the leaves of *Pilocarpus* species. This compound is a critical muscarinic acetylcholine receptor agonist, valued for its potent parasympathomimetic activity. It is an essential active pharmaceutical ingredient (API) for the ophthalmic and pharmaceutical industries, primarily used in the formulation of treatments for glaucoma and dry mouth (xerostomia).

Application

• Ophthalmic Solutions: Primary API in prescription eye drops for reducing intraocular pressure in the treatment of glaucoma and ocular hypertension.
• Pharmaceutical Formulations: Used in the development of systemic and topical medications for conditions like xerostomia (dry mouth) associated with Sjögren's syndrome or radiation therapy.
• Research & Development: A key reference standard and tool compound in pharmacological research for studying cholinergic systems and muscarinic receptor function.
• Diagnostic Agent: Employed in sweat tests (pilocarpine iontophoresis) for the diagnosis of cystic fibrosis.
• Veterinary Medicine: Used in ophthalmic preparations for animals to manage glaucoma.
• Chemical Synthesis: Serves as a chiral starting material or intermediate in the synthesis of more complex bioactive molecules.

Basic Information

Product Name	(+)-Pilocarpine Hydrochloride
CAS No.	54-71-7
Molecular Formula	C11H16N2O2 • HCl
Molecular Weight	244.72 g/mol
Synonyms	Pilocarpine HCl; (3S,4R)-3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one hydrochloride; Pilocarpine Hydrochloride USP; Pilocarpinium Chloride; Ocusert Pilo; Pilocar; Isopto Carpine; Pilocarpol; Pilokarpin; Pilomiotin
EINECS	200-212-3

Quality Control

Our (+)-Pilocarpine Hydrochloride is manufactured under strict quality management systems. It is typically supplied to meet or exceed USP/EP/BP monograph specifications, ensuring suitability for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identity, purity, and impurity profile verification. Certificates of Analysis (COA) are provided with every shipment, detailing all test results against relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Specific Rotation	+80° to +83° (c = 5 in H2O)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%
Microbial Enumeration	Meets USP/EP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.