Description

D-Penicillamine is a sulfur-containing amino acid derivative and a potent chelating agent, widely recognized for its role in heavy metal detoxification. Its primary commercial value lies in its high specificity for binding copper, lead, and mercury, making it a critical active pharmaceutical ingredient (API) and a valuable reagent in biochemical research. This compound is essential for manufacturers in the pharmaceutical, biotechnology, and fine chemical synthesis sectors, where it is used to produce chelation therapies and as a chiral building block.

Application

• Pharmaceutical API: Key ingredient in prescription medications for the treatment of Wilson's disease (copper overload), rheumatoid arthritis, and cystinuria.
• Heavy Metal Chelation Therapy: Used in formulations for lead and mercury poisoning, leveraging its strong metal-binding properties.
• Biochemical Research: Employed as a reducing agent to cleave disulfide bonds in proteins and enzymes for structural studies.
• Chiral Synthesis: Serves as a versatile chiral precursor or resolving agent in the asymmetric synthesis of complex organic molecules.
• Veterinary Medicine: Applied in veterinary pharmaceuticals for the treatment of copper-associated hepatopathies in animals.
• Reference Standard: Used in analytical laboratories as a high-purity standard for quality control and method validation in pharmacopeial testing (USP, EP).

Basic Information

Product Name	D-Penicillamine
CAS No.	52-67-5
Molecular Formula	C5H11NO2S
Molecular Weight	149.21 g/mol
Synonyms	D-3-Mercaptovaline; (R)-2-Amino-3-mercapto-3-methylbutanoic acid; D-β,β-Dimethylcysteine; D-3,3-Dimethylcysteine; Cuprenil; Depen; Metalcaptase; Mercaptyl; Artamin; Trolovol
EINECS	200-148-8

Quality Control

Our D-Penicillamine is manufactured under strict quality management systems. It is tested to meet or exceed relevant pharmacopeial standards, including USP and EP monographs, where applicable. Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles to ensure reliable performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥98.5%
Specific Rotation	+61.0° to +65.0° (c=1, 1N HCl)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.