Description

Homatropine Hydrobromide CAS NO 51-56-9 is a quaternary ammonium salt derivative of tropine, functioning as a competitive muscarinic acetylcholine receptor antagonist. This compound is valued for its potent mydriatic and cycloplegic properties, offering a shorter duration of action compared to atropine. It is a critical active pharmaceutical ingredient (API) primarily required by the ophthalmic pharmaceutical industry for the formulation of diagnostic and therapeutic eye drops.

Application

• Ophthalmic Solutions: Primary use as a mydriatic agent to dilate the pupil for retinal examination and refractive error diagnosis.
• Cycloplegic Formulations: Used to temporarily paralyze the ciliary muscle of the eye, facilitating accurate measurement of refractive errors.
• Uveitis Treatment: Incorporated into therapeutic regimens to relieve pain and prevent synechiae in inflammatory eye conditions.
• Pre-operative Ophthalmic Care: Employed in surgical procedures to achieve pupil dilation and cycloplegia.
• Pharmaceutical Intermediates: Serves as a key synthetic intermediate or reference standard in the research and development of anticholinergic drugs.
• Analytical Reference Standards: Used in quality control laboratories for the identification and assay of ophthalmic products via HPLC or other chromatographic methods.

Basic Information

Product Name	Homatropine Hydrobromide
CAS No.	51-56-9
Molecular Formula	C16H21NO3 • HBr
Molecular Weight	356.25 g/mol
Synonyms	Homatropine HBr; Homatropinium Bromide; Mandelyltropine Hydrobromide; Tropine Mandelate Hydrobromide; (8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate hydrobromide; 3α-Hydroxy-8-methyl-1αH,5αH-tropanium bromide (±)-tropate; Isopto Homatropine (brand name component); Ophthalmic Homatropine
EINECS	200-094-1

Quality Control

Our Homatropine Hydrobromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including compliance with relevant pharmacopoeial standards such as USP and EP. A detailed Certificate of Analysis (COA) documenting identity, purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.0%
Specific Rotation	-0.10° to +0.10° (in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.