Description

Imipramine is a tricyclic dibenzazepine-class compound, primarily recognized for its significant role as a foundational active pharmaceutical ingredient (API) in antidepressant medications. Its importance lies in its well-established mechanism of action, which involves the inhibition of norepinephrine and serotonin reuptake, making it a critical component in the synthesis of various neuropsychiatric therapeutics. This product is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of treatments for major depressive disorder and other related conditions.

Application

• Primary Active Pharmaceutical Ingredient (API) in the manufacture of antidepressant medications.
• Reference standard in analytical laboratories for quality control and method validation.
• Key intermediate in advanced pharmaceutical research and development of new CNS-active drugs.
• Used in preclinical and clinical studies investigating tricyclic antidepressant mechanisms.
• Essential material for compounding pharmacies requiring specific neuropsychiatric formulations.

Basic Information

Product Name	Imipramine
CAS No.	50-49-7
Molecular Formula	C19H24N2
Molecular Weight	280.41 g/mol
Synonyms	5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine; Imipramine Hydrochloride (salt form); Tofranil® (brand name); Imizin; Melipramine; Dimipressin; Antideprin; G-22355
EINECS	200-048-4

Quality Control

Our Imipramine is manufactured and tested under strict quality management systems to ensure it meets the high-purity standards required for pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, related substances, and residual solvents. We can supply material compliant with various pharmacopeial monographs, including USP and EP, upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.