Description

Amitriptyline is a tricyclic antidepressant (TCA) compound of significant pharmaceutical importance, widely recognized for its therapeutic efficacy. This active pharmaceutical ingredient (API) is critical for the formulation of medications used to treat major depressive disorders and certain chronic pain conditions. It is essential for pharmaceutical manufacturers, research institutions, and chemical distributors serving the global healthcare sector, requiring a reliable supply of high-purity material.

Application

• Pharmaceutical API: Primary use as the active ingredient in antidepressant and neuropathic pain relief medications.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in laboratories.
• Clinical Research: Utilized in preclinical and clinical studies investigating mechanisms of action and new therapeutic applications for tricyclic compounds.
• Generic Drug Manufacturing: A key component for companies producing generic versions of amitriptyline-based formulations.
• Biochemical Research: Used in neuroscience and pharmacology research to study neurotransmitter reuptake inhibition.

Basic Information

Product Name	Amitriptyline
CAS No.	50-48-6
Molecular Formula	C20H23N
Molecular Weight	277.40 g/mol
Synonyms	Amitriptyline Hydrochloride (common salt form); 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine; Elavil; Laroxyl; Saroten; Tryptizol; Amitril; Deprelin
EINECS	200-045-7

Quality Control

Our Amitriptyline is manufactured and tested under a strict quality management system to meet the rigorous standards of the pharmaceutical industry. We ensure compliance with relevant pharmacopoeial specifications (such as USP/EP) where applicable. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing purity, identity, and impurity profiles to guarantee supply reliability and product consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.