Description

Desipramine is a tricyclic dibenzazepine-class compound, widely recognized as the primary active metabolite of imipramine. This pharmaceutical intermediate is of critical importance in the synthesis and research of antidepressant medications, where its noradrenergic reuptake inhibition properties are key. It is essential for pharmaceutical manufacturers, research institutions, and chemical suppliers serving the global life sciences sector who require high-purity building blocks for active pharmaceutical ingredient (API) development and analytical reference standards.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of desipramine hydrochloride, a prescription antidepressant medication.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as the core chemical entity in the production of finished dosage forms.
• Biochemical Research: Used in neuroscience and pharmacology studies to investigate norepinephrine reuptake mechanisms and antidepressant action.
• Reference Standard: Critical for quality control laboratories to perform identity, assay, and impurity testing via HPLC, GC, or spectroscopy.
• Metabolite Standard: Employed in clinical and forensic toxicology to identify and quantify imipramine metabolism.
• Process Development & Scale-up: Utilized in optimizing synthetic routes and manufacturing processes for tricyclic antidepressants.

Basic Information

Product Name	Desipramine
CAS No.	50-47-5
Molecular Formula	C18H22N2
Molecular Weight	266.38 g/mol
Synonyms	Desmethylimipramine; Norimipramine; DMI; 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine; 5-(3-Methylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine; G-35020; JB-8181; NSC-114900; Pertofrane (brand name related)
EINECS	200-045-7

Quality Control

Our Desipramine is produced and tested under a strict quality management system. We offer material suitable for pharmaceutical research and development, with typical purity levels meeting or exceeding 98.0% (HPLC). Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Specifications can be aligned with client requirements for pharmacopeial standards (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.