Description

1,1'-(11As)-Dibenzo[D,F][1,3]Dioxepin-1,11-Diylbis[1,1-Diphenylphosphine is a sophisticated chiral bisphosphine ligand, a critical component in asymmetric catalysis for the synthesis of high-value, optically active compounds. Its unique dibenzo-dioxepin backbone and arsenic-bridged structure provide exceptional steric and electronic tuning, enabling highly selective transformations in pharmaceutical and fine chemical manufacturing. This advanced ligand is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel chiral molecules with high enantiomeric purity.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Asymmetric C-C Bond Formation: Catalyzes critical cross-coupling and addition reactions, such as Rhodium or Iridium-catalyzed allylic substitutions, for constructing complex chiral centers.
• Pharmaceutical Intermediate Production: Enables the scalable, stereoselective synthesis of active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and oncology.
• Agrochemical Synthesis: Used in the development of chiral herbicides, fungicides, and pesticides where biological activity is enantiomer-specific.
• Fine Chemical and Fragrance Manufacturing: Facilitates the production of enantiomerically pure flavors, fragrances, and other high-value specialty chemicals.
• Academic and Industrial R&D: Serves as a valuable tool for methodology development in organic synthesis and catalysis research within university and corporate laboratories.

Basic Information

Item	Details
Product Name	1,1'-(11As)-Dibenzo[D,F][1,3]Dioxepin-1,11-Diylbis[1,1-Diphenylphosphine
CAS No.	486429-92-9
Molecular Formula	C41H30AsO2P2
Molecular Weight	698.52 g/mol
Synonyms	(11As)-Dibenzo[d,f][1,3]dioxepin-1,11-diylbis(diphenylphosphine); As-Bridged Dibenzo[d,f][1,3]dioxepin Bisphosphine Ligand; (aS)-4,6:4',6'-Bis(ethylenedioxy)biphenyl-2,2'-diylbis(diphenylphosphine) arsenic analog; Chiral Arsenic-Bridged Bisphosphine; As-DBDPP (Arsenic-Dibenzo Dioxepin Phosphine); (11aS)-1,1'-(Dibenzo[d,f][1,3]dioxepine-1,11-diyl)bis(1,1-diphenylphosphine)
EINECS	Contact for details

Quality Control

Every batch of our 1,1'-(11As)-Dibenzo[D,F][1,3]Dioxepin-1,11-Diylbis[1,1-Diphenylphosphine is manufactured and tested under strict quality management systems to ensure high purity, consistent performance, and reliable enantiomeric excess. Our products undergo rigorous quality testing, including chiral HPLC and NMR analysis, to ensure compliance with industry standards for advanced catalytic ligands. Certificates of Analysis (COA) with full analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. This compound is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use to minimize exposure to air and humidity.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.