Description

4-(Hydroxymethyl)-2-(Trifluoromethyl)Benzoic Acid is a high-value trifluoromethylated benzoic acid derivative, serving as a critical multifunctional building block in advanced organic synthesis. Its unique structure, combining a carboxylic acid, a hydroxymethyl group, and a trifluoromethyl substituent, offers versatile reactivity for constructing complex molecules with enhanced properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with improved metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral research, where the trifluoromethyl group is prized for its lipophilicity and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl moiety to enhance biological activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, contributing to improved performance in display and lighting technologies.
• Polymer Modification: Acts as a monomer or cross-linking agent for introducing fluorine-containing groups into specialty polymers, improving chemical resistance and surface properties.
• Chemical Research & Development: A versatile building block in medicinal chemistry and material science for structure-activity relationship (SAR) studies and novel compound library synthesis.
• Fluorinated Surfactant Precursor: Can be utilized to synthesize specialty surfactants and surface modifiers with unique wetting and leveling characteristics.

Basic Information

Product Name	4-(Hydroxymethyl)-2-(Trifluoromethyl)Benzoic Acid
CAS No.	481075-46-1
Molecular Formula	C9H7F3O3
Molecular Weight	220.15 g/mol
Synonyms	2-(Trifluoromethyl)-4-(hydroxymethyl)benzoic acid; 4-(Hydroxymethyl)-2-trifluoromethylbenzoic acid; Benzoic acid, 4-(hydroxymethyl)-2-(trifluoromethyl)-; 2-Trifluoromethyl-4-hydroxymethylbenzoic acid; 4-Carboxy-3-(trifluoromethyl)benzyl alcohol; 3-(Trifluoromethyl)-4-(hydroxymethyl)benzoic acid; 481075-46-1; 4-Hydroxymethyl-2-trifluoromethylbenzoic acid
EINECS	Contact for details

Quality Control

Our 4-(Hydroxymethyl)-2-(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP and ISO 9001 compliant production for pharmaceutical-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.