Description

2-Fluoro-5-Hydroxymethyl-Benzoic Acid is a versatile fluorinated aromatic building block that combines a carboxylic acid group with a hydroxymethyl substituent on a fluorinated benzene ring. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of fluorinated drug candidates targeting CNS disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated monomers and compounds used in electronic displays and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorinated aromatic units into polymer backbones, improving material properties like chemical resistance, thermal stability, and optical characteristics.
• Peptide Mimetics & Bioconjugation: The carboxylic acid and hydroxymethyl groups allow for facile conjugation and are used in creating peptide analogs and linker molecules for bioconjugation chemistry.
• Chemical Research & Development: A valuable reagent in academic and industrial labs for exploring new fluorination chemistry and synthesizing novel aromatic compounds for material science.

Basic Information

Product Name	2-Fluoro-5-Hydroxymethyl-Benzoic Acid
CAS No.	481075-38-1
Molecular Formula	C8H7FO3
Molecular Weight	170.14 g/mol
Synonyms	5-(Hydroxymethyl)-2-fluorobenzoic Acid; 2-Fluoro-5-(hydroxymethyl)benzoic Acid; Benzoic acid, 2-fluoro-5-(hydroxymethyl)-; 2-Fluoro-5-hydroxymethylbenzoic acid; 2-Fluoro-5-(hydroxymethyl)benzoic acid; 2-Fluoro-5-hydroxy-methyl-benzoic acid; 2-Fluoro-5-(hydroxymethyl)benzoic acid (CAS 481075-38-1)
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-Hydroxymethyl-Benzoic Acid is produced under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. Our quality commitment includes adherence to cGMP principles where applicable, and comprehensive Certificates of Analysis (COA) detailing purity, impurity profiles, and physical data are provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent moisture absorption and potential degradation. Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.