Description

2-Fluoro-3-Hydroxymethyl-Benzoic Acid is a high-purity fluorinated benzoic acid derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a carboxylic acid and a hydroxymethyl group on a fluorinated aromatic ring, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine atoms and functional handles into their target compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity, stability, and metabolic profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer Modification: Employed to introduce polar functional groups and fluorine into polymer backbones, enhancing material properties like chemical resistance, surface energy, and adhesion.
• Peptide Mimetics & Bioconjugation: The carboxylic acid and hydroxymethyl groups facilitate its use in creating fluorinated amino acid analogs and linker molecules for bioconjugation chemistry.
• Chemical Research & Development: A valuable reagent for method development in fluorination chemistry and for exploring new reaction pathways in academic and industrial R&D settings.

Basic Information

Product Name	2-Fluoro-3-Hydroxymethyl-Benzoic Acid
CAS No.	481075-37-0
Molecular Formula	C8H7FO3
Molecular Weight	170.14 g/mol
Synonyms	3-(Hydroxymethyl)-2-fluorobenzoic Acid; 2-Fluoro-3-(hydroxymethyl)benzoic Acid; Benzoic acid, 2-fluoro-3-(hydroxymethyl)-; 2-Fluoro-3-hydroxy-methylbenzoic Acid; 2-Fluoro-3-carbinol Benzoic Acid; 2-F-3-HMBA; 481075-37-0; 2-Fluoro-3-(hydroxymethyl)benzoic acid
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-Hydroxymethyl-Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.