Description

2-Butoxy-5-Fluorophenylboronic Acid is a specialized organoboron compound that serves as a crucial building block in modern synthetic chemistry. Its value lies in its dual functionality, where the boronic acid group enables efficient cross-coupling reactions, and the alkoxy-fluorophenyl scaffold provides unique electronic and steric properties. This high-purity intermediate is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the fluorinated aromatic structure for enhanced bioactivity.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where the fluorophenyl unit can modify charge transport properties.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing sophisticated ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical and CDMO companies producing bespoke compounds for client projects.

Basic Information

Product Name	2-Butoxy-5-Fluorophenylboronic Acid
CAS No.	480438-62-8
Molecular Formula	C₁₀H₁₄BFO₃
Molecular Weight	212.03 g/mol
Synonyms	(2-Butoxy-5-fluorophenyl)boronic acid; 5-Fluoro-2-butoxybenzeneboronic acid; 2-Butoxy-5-fluorobenzeneboronic acid; Boronic acid, B-(2-butoxy-5-fluorophenyl)-; 480438-62-8; 2-Butoxy-5-fluorophenyl-B(OH)₂
EINECS	Contact for details

Quality Control

Our 2-Butoxy-5-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.