Description

D-[4,5,6-13C3]Glucose is a stable isotope-labeled analog of D-glucose, specifically enriched with carbon-13 at the 4, 5, and 6 positions. This high-purity labeled compound is essential for advanced metabolic research, enabling precise tracking and quantification of glucose utilization and flux in complex biological systems. It is a critical reagent for researchers and analytical laboratories in pharmaceutical development, clinical diagnostics, and nutritional science who require uncompromised isotopic purity and chemical stability for tracer studies.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to map intracellular metabolic pathways and quantify reaction rates in cell cultures, tissues, and whole organisms.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as an internal standard in LC-MS and GC-MS for the accurate quantification of glucose and its metabolites in biological matrices during drug development studies.
• Clinical Research: Employed in studies investigating glucose metabolism disorders, such as diabetes, obesity, and cancer metabolism.
• Nutritional Science: Utilized in tracer studies to understand dietary glucose absorption, distribution, and metabolism in humans and animals.
• Biomarker Discovery: Acts as a standard in metabolomics and proteomics research for identifying and validating disease-specific metabolic signatures.
• Enzyme Mechanism Studies: Provides insights into the catalytic mechanisms of glycolytic and gluconeogenic enzymes through isotopic labeling.

Basic Information

Product Name	D-[4,5,6-13C3]Glucose
CAS No.	478529-47-4
Molecular Formula	C313C3H12O6
Molecular Weight	183.12 g/mol (for 13C3 isotopologue)
Synonyms	D-Glucose-4,5,6-13C3; (4,5,6-13C3)-D-Glucose; D-(+)-Glucose-4,5,6-13C3; D-Glucose (4,5,6-13C3); 13C3-Labeled D-Glucose; Isotopic D-Glucose; 4,5,6-13C3-D-Glucopyranose; Stable Isotope-Labeled Glucose
EINECS	Contact for details

Quality Control

Every batch of D-[4,5,6-13C3]Glucose is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm isotopic enrichment and positional labeling. Certificates of Analysis (COA) detailing isotopic purity, chemical purity, and specific analytical data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Purity (13C)	≥ 99 atom % 13C
Isotopic Enrichment (Position 4,5,6)	≥ 98% (each position)
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	+52.5° to +53.0° (c=10, H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.