Description

D-[4,6-13C2]Glucose is a stable isotope-labeled analog of D-glucose, specifically enriched with carbon-13 at the 4 and 6 positions. This high-purity compound is essential for advanced metabolic research, enabling precise tracking and quantification of glucose utilization and flux in biological systems. It is a critical reagent for scientists and manufacturers in pharmaceutical R&D, clinical diagnostics, and nutritional studies who require reliable, isotopically pure tracers.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to map and quantify intracellular metabolic pathways in cell cultures, tissues, and whole organisms.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in isotope dilution mass spectrometry for the accurate quantification of glucose and its metabolites in preclinical and clinical studies.
• In Vitro Diagnostic (IVD) Development: Serves as a calibrator or internal standard in mass spectrometry-based clinical assays for diabetes management and metabolic disorder diagnostics.
• Nutritional Research: Utilized in human and animal studies to investigate glucose absorption, turnover, and energy metabolism under various dietary conditions.
• Biopharmaceutical Production: Applied in cell culture media for monitoring nutrient consumption and optimizing bioreactor conditions in the production of therapeutic proteins and vaccines.
• Stable Isotope Labeling: Acts as a precursor for the synthesis of other 13C-labeled metabolites and complex biomolecules.

Basic Information

Item	Detail
Product Name	D-[4,6-13C2]Glucose
CAS No.	478529-45-2
Molecular Formula	C6H12O6 (with 13C at positions 4 & 6)
Molecular Weight	182.15 g/mol (approx., based on isotopic enrichment)
Synonyms	D-Glucose-4,6-13C2; (4,6-13C2)-D-Glucose; 13C2-Labeled D-Glucose; D-Glucose (4,6-13C2); Isotopic Glucose Tracer; 1,3,4,5,6-Pentahydroxyhexan-2-one-4,6-13C2; Stable Isotope-Labeled Glucose; Metabolic Tracer Glucose
EINECS	Contact for details

Quality Control

Every batch of D-[4,6-13C2]Glucose is manufactured and analyzed under strict quality protocols to ensure exceptional isotopic and chemical purity. Our products undergo rigorous quality testing, including NMR and LC-MS, to ensure compliance with the stringent requirements of research and diagnostic applications. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and specific tests are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Isotopic Enrichment	≥ 99 atom % 13C (at positions 4 & 6)
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	+52.5° to +53.0° (c=10 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Bacterial Endotoxins	< 0.25 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.