Description

D-[6-13C,6,6'-2H2]Glucose is a high-purity, isotopically labeled derivative of glucose, specifically enriched with carbon-13 at the 6-position and deuterium at both 6-positions. This compound is an essential tool for advanced metabolic research, enabling precise tracing and quantification of glucose utilization and metabolic flux in complex biological systems. It is primarily utilized by researchers and scientists in pharmaceutical development, clinical diagnostics, and academic biochemistry for applications such as stable isotope-resolved metabolomics (SIRM) and drug metabolism studies.

Application

• Stable Isotope-Resolved Metabolomics (SIRM): Used as a tracer to map detailed metabolic pathways and quantify flux in cell cultures, tissues, and whole organisms.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in pharmaceutical R&D to study the metabolic fate of new drug candidates and their interaction with glucose metabolism.
• Clinical Research & Diagnostics: Facilitates investigations into metabolic disorders such as diabetes, cancer metabolism, and insulin resistance by providing precise metabolic data.
• Biochemical Pathway Analysis: Serves as a critical substrate for elucidating glycolysis, the pentose phosphate pathway, and other central carbon metabolic routes.
• NMR & Mass Spectrometry Standards: Acts as an internal standard or reference material for quantitative analysis using NMR spectroscopy and LC-MS/MS.

Basic Information

Product Name	D-[6-13C,6,6'-2H2]Glucose
CAS No.	478529-33-8
Molecular Formula	C6H102H213CO6
Molecular Weight	184.15 g/mol (for 13C12H2 labeled form)
Synonyms	D-Glucose-6-13C,6,6-d2; (6-13C,6,6'-2H2)-D-Glucose; 6-13C,6,6'-dideutero-D-glucose; Isotopically Labeled D-Glucose; D-Glucose (6-13C,6,6'-2H2); Stable Isotope Labeled Glucose; Metabolic Tracer Glucose; [6-13C,6,6'-2H2]-D-Glucopyranose
EINECS	Contact for details

Quality Control

Every batch of D-[6-13C,6,6'-2H2]Glucose is manufactured and analyzed under strict quality systems to ensure exceptional isotopic and chemical purity for research applications. Our products undergo rigorous quality testing, including isotopic enrichment verification by NMR and MS, chemical purity assessment by HPLC, and stringent controls for moisture and impurities. Certificates of Analysis (COA) detailing isotopic purity, chemical purity, and specific tests are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions or under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (13C)	≥ 99 atom % 13C
Isotopic Enrichment (2H)	≥ 98 atom % 2H
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Specific Optical Rotation	+52.5° to +53.5° (c=10, H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.