Description

D-[1,2,3-13C3]Glucose is a stable isotope-labeled analog of D-glucose, where three carbon atoms at positions 1, 2, and 3 are enriched with the non-radioactive carbon-13 isotope. This high-purity compound is essential for advanced metabolic research, enabling precise tracking and quantification of glucose utilization and metabolic flux in biological systems. It is a critical reagent for scientists and manufacturers in pharmaceutical R&D, clinical diagnostics, and nutritional studies who require the highest standards of isotopic purity and chemical stability for accurate mass spectrometry and NMR analysis.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to map and quantify intracellular metabolic pathways in cell cultures, tissues, and whole organisms.
• Pharmaceutical Research: Employed in drug metabolism and pharmacokinetics (DMPK) studies to investigate the effects of new drug candidates on glucose metabolism.
• Clinical Diagnostics Development: Serves as an internal standard in LC-MS/MS and GC-MS methods for the accurate measurement of glucose and related metabolites in biological fluids.
• Nutritional Science: Applied in studies to understand dietary carbohydrate metabolism, insulin resistance, and metabolic disorders like diabetes.
• Biotechnology & Fermentation: Used to optimize microbial and mammalian cell culture processes by analyzing carbon source utilization and product yield.
• Biochemical Research: A key tool for enzymology studies, investigating the mechanisms of glycolytic and gluconeogenic enzymes.

Basic Information

Product Name	D-[1,2,3-13C3]Glucose
CAS No.	478529-32-7
Molecular Formula	C3¹³C3H12O6
Molecular Weight	185.13 g/mol
Synonyms	D-Glucose-¹³C3 (1,2,3); [1,2,3-¹³C3]-D-Glucose; D-(+)-Glucose-¹³C3; ¹³C3-Labeled D-Glucose; Isotopic D-Glucose; Stable Isotope-Labeled Glucose; D-Glucose (U-¹³C3) (common but not exact); 6-(hydroxymethyl)oxane-2,3,4,5-tetrol-¹³C3
EINECS	Contact for details

Quality Control

Every batch of D-[1,2,3-13C3]Glucose is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure it meets the exacting requirements for isotopic and chemical purity in research and diagnostic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters including isotopic enrichment (Atom % ¹³C), chemical purity by HPLC, and specific optical rotation. Our quality commitment aligns with the standards expected for high-value research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (chemical purity)
Isotopic Enrichment	≥ 99 atom % ¹³C (at positions 1,2,3)
Specific Optical Rotation	+52.5° to +53.0° (c=10 in H2O)
Water Content (KF)	≤ 1.0 %
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.