Description

D-[4,5-13C2]Glucose is a stable isotope-labeled analog of D-glucose, specifically enriched with carbon-13 at the 4 and 5 positions. This precise labeling makes it an indispensable tool for advanced metabolic research and flux analysis, providing critical insights into cellular energy pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for tracer studies, NMR spectroscopy, and mass spectrometry applications.

Application

• Metabolic Flux Analysis (MFA): Used as a stable isotopic tracer to quantify intracellular metabolic reaction rates in biological systems.
• NMR Spectroscopy: Serves as a substrate for 13C-NMR studies to elucidate metabolic pathways and enzyme mechanisms.
• Mass Spectrometry (MS): Employed as an internal standard for the accurate quantification of glucose and its metabolites via LC-MS or GC-MS.
• Pharmaceutical Research: Facilitates drug metabolism and pharmacokinetics (DMPK) studies to track the fate of glucose-derived carbons.
• Biotechnology & Fermentation: Applied in optimizing microbial cell factories and bioprocesses by tracing carbon utilization.
• Clinical Diagnostics Development: Used in the research and development of advanced diagnostic assays for metabolic disorders like diabetes.

Basic Information

Product Name	D-[4,5-13C2]Glucose
CAS No.	478529-31-6
Molecular Formula	C6H12O6 (with 13C at positions 4 & 5)
Molecular Weight	182.15 g/mol (for 13C2 labeled form)
Synonyms	D-Glucose-4,5-13C2; (4,5-13C2)-D-Glucose; D-Glucose (4,5-13C2); [4,5-13C2]Glucose; 13C Labeled D-Glucose; Isotopic D-Glucose; Stable Isotope-Labeled Glucose; Dextrose-4,5-13C2
EINECS	Contact for details

Quality Control

Our D-[4,5-13C2]Glucose is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity confirmation. We adhere to relevant industry standards for stable isotope-labeled compounds to ensure batch-to-batch consistency and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Isotopic Enrichment (13C at C4 & C5)	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	+52.5° to +53.0° (c=10, H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.