Description

2-Deoxy-2-Fluoro-D-[1-13C]Glucose is a stable isotope-labeled derivative of the widely used metabolic tracer, fluorodeoxyglucose (FDG). This compound is specifically designed for advanced research in nuclear medicine and molecular imaging, offering a unique carbon-13 label at the C-1 position for precise metabolic pathway tracking. It is an essential tool for scientists and pharmaceutical developers in the fields of PET (Positron Emission Tomography) radiopharmaceutical research, metabolic flux analysis, and drug development. The product is critical for studies requiring high specificity in tracing glucose metabolism and glycolysis in various disease models.

Application

• Precursor for Carbon-13 Labeled PET Tracers: Serves as a key intermediate in the synthesis of [13C]-labeled FDG for advanced PET imaging studies.
• Metabolic Flux Analysis (MFA): Used with NMR or LC-MS to quantitatively map intracellular metabolic pathways in cancer, neurological, and metabolic disease research.
• Radiopharmaceutical Reference Standard: Acts as a non-radioactive reference compound for quality control and method development in radiopharmacy.
• Biochemical Research: Employed in enzyme kinetics studies, particularly for hexokinase and glucose transporters, due to its stable isotope label.
• Drug Discovery & Development: Utilized in preclinical studies to investigate the mechanism of action of novel oncology and metabolic disorder therapeutics.
• Academic & Institutional Research: Fundamental tool for universities and research institutes exploring cellular metabolism and bioenergetics.

Basic Information

Product Name	2-Deoxy-2-Fluoro-D-[1-13C]Glucose
CAS No.	478518-95-5
Molecular Formula	C6H11FO5 (13C1)
Molecular Weight	182.15 g/mol (for 13C1 isotopologue)
Synonyms	2-Deoxy-2-fluoro-D-glucose-1-13C; [1-13C]-2-FDG; 2-Fluoro-2-deoxy-D-[1-13C]glucose; FDG-1-13C; 1-13C-2-Fluoro-2-deoxy-D-glucose; (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-((13C)hydroxymethyl)tetrahydrofuran-3,4-diol; Non-radioactive 13C-FDG precursor
EINECS	Contact for details

Quality Control

Every batch of 2-Deoxy-2-Fluoro-D-[1-13C]Glucose is manufactured and analyzed under strict quality systems to ensure identity, purity, and isotopic enrichment meet the exacting standards required for research and development. Our quality assurance includes comprehensive testing via NMR (Nuclear Magnetic Resonance), HPLC (High-Performance Liquid Chromatography), and Mass Spectrometry to confirm chemical and isotopic purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom % 13C
Chemical Purity (NMR)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.