Description

[2'-13C]Uridine is a stable isotope-labeled nucleoside, specifically labeled with carbon-13 at the 2' position of the ribose sugar. This high-purity labeled compound is essential for advanced metabolic research, providing a critical tool for tracing biochemical pathways with precision. It is primarily utilized by pharmaceutical researchers, academic institutions, and CROs engaged in drug metabolism and pharmacokinetics (DMPK) studies, metabolic flux analysis, and NMR spectroscopy.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as an internal standard or tracer to quantitatively analyze the metabolism of nucleoside-based drugs.
• Metabolic Flux Analysis (MFA): Enables precise tracking of carbon flow through central metabolic pathways like the pentose phosphate pathway and nucleotide synthesis.
• NMR Spectroscopy: Serves as a valuable probe for structural and dynamic studies of RNA and ribonucleoprotein complexes due to the 13C label.
• Biochemical Pathway Tracing: Investigates pyrimidine salvage and synthesis pathways in cell culture and in vivo models.
• Mass Spectrometry (MS) Internal Standard: Provides high-accuracy quantification of uridine and its metabolites in complex biological samples via LC-MS/MS.
• Virology and Oncology Research: Used in studies targeting viral replication or cancer cell proliferation, which are dependent on nucleotide metabolism.

Basic Information

Product Name	[2'-13C]Uridine
CAS No.	478511-11-4
Molecular Formula	C9H1213CN2O6
Molecular Weight	Contact for details
Synonyms	2'-Carbon-13 labeled Uridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-((2-13C)hydroxymethyl)oxolan-2-yl)pyrimidine-2,4-dione; Uridine-2'-13C; [2'-13C]-1-β-D-Ribofuranosyluracil; 13C Labeled Uridine; Isotopic Uridine; Stable Isotope-Labeled Nucleoside
EINECS	Contact for details

Quality Control

Our [2'-13C]Uridine is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C), chemical purity (by HPLC), and identity confirmation. We adhere to relevant industry guidelines for stable isotope-labeled compounds to ensure reliability and reproducibility in your research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98%
Isotopic Enrichment	≥99 atom % 13C
Isotopic Purity (MS)	≥99%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.