Description

[5'-13C]2'-Deoxyadenosine Monohydrate is a stable isotope-labeled nucleoside analog, specifically deuterated at the 5' carbon position. This labeling is critical for providing an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in pharmacokinetic and metabolic studies. It is an essential research tool for scientists in pharmaceutical development, clinical diagnostics, and biochemistry who require precise quantification of deoxyadenosine and related metabolites.

Application

• Mass Spectrometry Internal Standard: Serves as a critical quantitative reference in LC-MS/MS and GC-MS analyses for drug metabolism and pharmacokinetics (DMPK) studies.
• Nucleic Acid Research: Used in metabolic tracing experiments to study DNA synthesis, repair mechanisms, and nucleotide pool dynamics.
• Biomarker Development: Enables the accurate measurement of deoxyadenosine levels in biological fluids for diagnostic assay development.
• Pharmaceutical Analysis: Employed in the quality control and bioanalytical testing of nucleoside-based antiviral and anticancer drugs.
• Metabolomics: Facilitates precise quantification in pathway analysis and flux studies within cellular metabolism.

Basic Information

Product Name	[5'-13C]2'-Deoxyadenosine Monohydrate
CAS No.	478510-77-9
Molecular Formula	C10¹³CH15N5O4 • H2O
Molecular Weight	Contact for details
Synonyms	2'-Deoxyadenosine-5'-13C Monohydrate; 9-[(2R,3S,5R)-3-Hydroxy-5-(hydroxymethyl-13C)oxolan-2-yl]-6-aminopurine Monohydrate; 13C-Labeled 2'-Deoxyadenosine; dA-5'-13C; Adenine Deoxyriboside-5'-13C; Stable Isotope-Labeled Deoxyadenosine; 2'-Deoxy-5'-13C-adenosine
EINECS	Contact for details

Quality Control

Every batch of [5'-13C]2'-Deoxyadenosine Monohydrate is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical purity and MS for isotopic enrichment. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and isotopic abundance.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Isotopic Enrichment	≥ 98 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	4.0% - 7.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.