Description

D-[2,3,4,5-13C4]Ribose is a stable isotope-labeled analog of the essential pentose sugar, D-ribose, where four carbon atoms are enriched with the 13C isotope. This high-purity labeled compound is critical for advanced research requiring precise metabolic tracing and quantification. It is primarily utilized by scientists and manufacturers in the fields of nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and metabolic flux analysis to study biochemical pathways with unparalleled accuracy.

Application

• Metabolic Pathway Tracing: Used as a tracer in in vitro and in vivo studies to elucidate nucleotide, cofactor, and energy metabolism pathways.
• Quantitative NMR (qNMR): Serves as an internal standard for the accurate quantification of metabolites and impurities in complex biological matrices.
• Mass Spectrometry (MS) Standards: Provides a stable isotope-labeled internal standard for LC-MS and GC-MS methods, enhancing the precision and accuracy of analyte measurement.
• Pharmaceutical Research: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the incorporation of ribose into novel therapeutic compounds, such as nucleoside analogs.
• Biochemical Research: Essential for studying the biosynthesis of RNA, ATP, and other critical biomolecules in cellular systems.
• Diagnostic Development: Used in the development of advanced clinical diagnostics based on metabolic profiling.

Basic Information

Product Name	D-[2,3,4,5-13C4]Ribose
CAS No.	478506-23-9
Molecular Formula	C1[13C]4H10O5
Molecular Weight	154.10 g/mol (for 13C4 labeled form)
Synonyms	D-Ribose-13C4; (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal-13C4; D-(-)-Ribose-13C4; Ribose (D-, 13C4); D-Ribose (2,3,4,5-13C4); Stable Isotope Labeled D-Ribose; 13C4-D-Ribose
EINECS	Contact for details

Quality Control

Every batch of D-[2,3,4,5-13C4]Ribose is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Our quality commitment includes verification of isotopic enrichment (≥ 99% 13C atom), chemical purity (by HPLC), and specific optical rotation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for identity, purity, isotopic enrichment, and residual solvents is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (chemical purity)
Isotopic Enrichment	≥ 99% 13C atom (at positions 2,3,4,5)
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.